ESPN NFL 2K5 is an American football video game developed by Visual Concepts for the PlayStation 2 and Xbox consoles. Published by Sega Sports and the Sega Corporation, it is the sixth installment of the NFL 2K series and the last to use official NFL licensing until an unnamed sequel is released in 2021. Gameplay is presented as a live ESPN television broadcast and features the voices and digital likenesses of multiple ESPN on-air personalities.

The game was originally released on July 20, 2004. It was the last NFL 2K game to be released before Electronic Arts (EA) signed an exclusive rights agreement with the National Football League (NFL) to make 2K's rival Madden NFL series the only officially licensed NFL game and was also the last game still being developed by Sega.