This game is based on the animated television series Family Guy. It was also released for the PlayStation 2 and the original Xbox.

The game is split into 22 levels for the three playable characters: Peter, Stewie or Brian. Peter and Stewie have eight levels, while Brian has six. Each character has his own unique style of play.

A key feature of the game are mini-games done in the same style as the cutaway gags that the show is famous for, usually lasting less than 10 seconds. The mini-games often repeat cutaway gags from the shows, such as Peter inexplicably burning his hand in a waffle iron. Successfully completing the mini-game offers a bonus: Brian becomes invisible for a short period, while Peter and Stewie receive power-ups for their respective abilities.