In celebration of the 25th Anniversary of the Harvest Moon franchise, Harvest Moon: The Winds of Anthos will offer new functions while keeping the core fundamentals that has made the series so popular. The land players will explore is known as Anthos, and is home to the Harvest Sprites, spirits that protect people and nature, as well as the goddess of nature known as the Harvest Goddess.

However, about 20 years ago, an unprecedented eruption in Anthos's volcanic region forced the Harvest Goddess and her Harvest Sprites to use all of their powers to protect the people. The people were saved, but the eruption left the villages cut off from each other... Believing that the separated villages and people would one day be reconnected, the Harvest Goddess sent a bottle into the ocean with a letter and a magic key, then fell into a deep sleep...