Sims can open their own shops and restaurants, and lead their business to great success (or dismal failure!) through careful management and competent customer service. As the boss of their new businesses, players' Sims are responsible for hiring and firing. Some employees are dedicated to their duties while others just put in time for a paycheck, so grooming an efficient staff can be a rewarding challenge.

Like earlier Sims expansion packs, Open for Business adds over 100 new objects to the game, many of which can be used at home as well as at work. Cash registers and service counters, awnings and elevators, and a wide selection of costumes and uniforms become available with the add-on. New areas are offered for builders, where they can custom-create the retail shop of their Sims' dreams.