Marvel Super Hero Squad: Comic Combat is a video game that uses the uDraw GameTablet, developed by Griptonite Games, and published by THQ and Vivendi Games. The game is the third in the Marvel Super Hero Squad franchise, acting as the sequel to two video games Marvel Super Hero Squad and Marvel Super Hero Squad: The Infinity Gauntlet. It was released on November 15, 2011 for the uDraw GameTablet, PlayStation 3, Xbox 360, and Nintendo Wii game systems.

Based on characters from Marvel comic books such as Thor and Iron Man, Marvel Super Hero Squad: Comic Combat revolves around Doctor Doom and his minions planning to find a way into the real world to steal the uDraw GameTablet and use it to take over the comic book universe.