Spider-Man: Web of Shadows is a video game title encompassing three versions: a full-3D action game for Microsoft Windows, PlayStation 3, Wii, and Xbox 360; a 2.5D sidescrolling beat em up action game for the PlayStation Portable and PlayStation 2 (called Amazing Allies Edition), and a 2.5D side-scrolling brawler/platformer for the Nintendo DS.

Spider-Man: Web of Shadows, along with most other games published by Activision that had used the Marvel licence, was de-listed and removed from all digital storefronts on January 1, 2014.